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May 3, 2017 Day104 of the First Year - History

May 3, 2017 Day104 of the First Year - History


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10:30AM THE PRESIDENT will receive his daily intelligence briefing

Oval Office

Closed Press

11:50AM THE PRESIDENT welcomes President Mahmoud Abbas of the Palestinian Authority

Stakeout

Open Press

11:55AM THE PRESIDENT meets with President Abbas

Oval Office

12:15PM THE PRESIDENT gives a joint statement with President Abbas

Roosevelt Room

12:30PM THE PRESIDENT will have a working luncheon with President Abbas

Cabinet Room

6:30PM THE PRESIDENT has dinner with religious leaders

Blue Room



Jamestown settlers arrive

Some 100 English colonists arrive along the east bank of the James River in Virginia to found Jamestown, the first permanent English settlement in North America. Dispatched from England by the London Company, the colonists had sailed across the Atlantic aboard the Susan Constant, Godspeedਊnd Discovery.

Upon landing at Jamestown, the first colonial council was held by seven settlers whose names had been chosen and placed in a sealed box by King James I. The council, which included Captain John Smith, an English adventurer, chose Edward Wingfield as its first president. After only two weeks, Jamestown came under attack from warriors from the local Algonquian confederacy, but the Native Americans were repulsed by the armed settlers. In December of the same year, John Smith and two other colonists were captured by Algonquians while searching for provisions in the Virginia wilderness. His companions were killed, but he was spared, according to a later account by Smith, because of the intercession of Pocahontas, Chief Powhatan’s daughter.

During the next two years, disease, starvation, and more Native American attacks wiped out most of the colony, but the London Company continually sent more settlers and supplies. The severe winter of 1609 to 1610, which the colonists referred to as the “starving time,” killed most of the Jamestown colonists, leading the survivors to plan a return to England in the spring. However, on June 10, Thomas West De La Warr, the newly appointed governor of Virginia, arrived with supplies and convinced the settlers to remain at Jamestown. In 1612, John Rolfe cultivated the first tobacco at Jamestown, introducing a successful source of livelihood. On April 5, 1614, Rolfe married Pocahontas, thus assuring a temporary peace with Chief Powhatan.

The death of Powhatan in 1618 brought about a resumption of conflict with the Algonquians, including an attack led by Chief Opechancanough in 1622 that nearly wiped out the settlement. The English engaged in violent reprisals against the Algonquians, but there was no further large-scale fighting until 1644, when Opechancanough led his last uprising and was captured and executed at Jamestown. In 1646, the Algonquian Confederacy agreed to give up much of its territory to the rapidly expanding colony, and, beginning in 1665, its chiefs were appointed by the governor of Virginia.


Development Timeline for Keytruda

DateArticle
May 5, 2021 Approval FDA Approves Merck’s Keytruda (pembrolizumab) Combined With Trastuzumab and Chemotherapy as First-line Treatment in Locally Advanced Unresectable or Metastatic HER2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma
Mar 23, 2021 Approval FDA Approves Merck’s Keytruda (pembrolizumab) Plus Platinum- and Fluoropyrimidine-Based Chemotherapy for Treatment of Certain Patients With Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction (GEJ) Carcinoma
Mar 1, 2021Merck Provides Update on Keytruda (pembrolizumab) Indication in Metastatic Small Cell Lung Cancer in the US
Nov 13, 2020 Approval FDA Approves Merck’s Keytruda (pembrolizumab) in Combination With Chemotherapy for Patients With Locally Recurrent Unresectable or Metastatic Triple‑Negative Breast Cancer Whose Tumors Express PD-L1 (CPS ≥10)
Oct 15, 2020 Approval FDA Approves Expanded Indication for Merck’s Keytruda (pembrolizumab) in Adult Patients With Relapsed or Refractory Classical Hodgkin Lymphoma (cHL)
Jun 29, 2020 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for First-Line Treatment of Patients With Unresectable or Metastatic MSI-H or dMMR Colorectal Cancer
Jun 24, 2020 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for the Treatment of Patients with Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (cSCC) that is Not Curable by Surgery or Radiation
Jun 17, 2020 Approval FDA Approves Second Biomarker-Based Indication for Merck’s Keytruda (pembrolizumab), Regardless of Tumor Type
Apr 28, 2020 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for Use at an Additional Recommended Dose of 400 mg Every Six Weeks for All Approved Adult Indications
Jan 8, 2020 Approval FDA Approves Keytruda (pembrolizumab) for Patients With BCG-Unresponsive, High-Risk, Non-Muscle Invasive Bladder Cancer
Sep 17, 2019 Approval FDA Approves Keytruda (pembrolizumab) plus Lenvima (lenvatinib) Combination Treatment for Patients with Certain Types of Endometrial Carcinoma
Jul 31, 2019 Approval FDA Approves Keytruda (pembrolizumab) for Recurrent Locally Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
Jun 18, 2019 Approval FDA Approves Keytruda (pembrolizumab) for the Treatment of Metastatic Small Cell Lung Cancer (SCLC)
Jun 11, 2019 Approval FDA Approves Keytruda (pembrolizumab) for First-Line Treatment of Head and Neck Squamous Cell Carcinoma
Apr 22, 2019 Approval FDA Approves Keytruda (pembrolizumab) in Combination With Inlyta (axitinib) as First-Line Treatment for Patients With Advanced Renal Cell Carcinoma (RCC)
Apr 11, 2019 Approval FDA Approves Expanded Monotherapy Label for Merck’s Keytruda (pembrolizumab) for First-Line Treatment of NSCLC
Feb 19, 2019 Approval FDA Approves Keytruda (pembrolizumab) for the Adjuvant Treatment of Patients with Melanoma with Involvement of Lymph Node(s) Following Complete Resection
Dec 19, 2018 Approval FDA Approves Keytruda (pembrolizumab) for the Treatment of Patients with Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma
Nov 9, 2018 Approval FDA Approves Keytruda (pembrolizumab) for the Treatment of Patients with Hepatocellular Carcinoma (HCC) Who Have Been Previously Treated with Sorafenib
Oct 30, 2018 Approval FDA Approves Keytruda (pembrolizumab) in Combination with Carboplatin and Either Paclitaxel or Nab-Paclitaxel for the First-Line Treatment of Patients with Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
Aug 21, 2018 Approval FDA Approves Expanded Label for Merck’s Keytruda (pembrolizumab) in Patients with Metastatic Nonsquamous NSCLC with No EGFR or ALK Genomic Tumor Aberrations
Jun 13, 2018 Approval FDA Approves Keytruda (pembrolizumab) for Treatment of Refractory or Relapsed Primary Mediastinal Large B-Cell Lymphoma (PMBCL)
Jun 12, 2018 Approval FDA Approves Keytruda (pembrolizumab) for Previously Treated Patients with Recurrent or Metastatic Cervical Cancer Whose Tumors Express PD-L1
Sep 22, 2017 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for Previously Treated Patients with Recurrent Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer Whose Tumors Express PD-L1
May 23, 2017 Approval FDA Approves Keytruda (pembrolizumab) as First Cancer Treatment for any Solid Tumor with a Specific Genetic Feature
May 18, 2017 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for Certain Patients with Locally Advanced or Metastatic Urothelial Carcinoma
May 10, 2017 Approval FDA Approves Merck’s Keytruda (pembrolizumab) as First-Line Combination Therapy for Patients with Metastatic Nonsquamous Non-Small Cell Lung Cancer (NSCLC), Irrespective of PD-L1 Expression
Mar 15, 2017 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for Classical Hodgkin Lymphoma (cHL)
Oct 24, 2016 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for First-Line Treatment of Certain Patients with Metastatic Non-Small Cell Lung Cancer
Aug 5, 2016 Approval FDA Approves Merck’s Keytruda (pembrolizumab) for Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Dec 18, 2015 Approval FDA Approves Expanded Indication for Keytruda (pembrolizumab) for the Treatment of Patients with Advanced Melanoma
Oct 2, 2015 Approval FDA Approves Keytruda (pembrolizumab) for Advanced Non-Small Cell Lung Cancer
Sep 4, 2014 Approval FDA Approves Keytruda (pembrolizumab) for Advanced Melanoma
Sep 2, 2014Merck to Present New Data in Five Tumor Types from Studies Evaluating Pembrolizumab
Jun 30, 2014Merck’s Investigational Anti-PD-1 Antibody, Pembrolizumab, Under Regulatory Review in Europe for Advanced Melanoma

May 3, 2017 Day104 of the First Year - History

Memorial Day is a national holiday in the United States. It is a day to remember those who have died serving our country.

  • May 28, 2012
  • May 27, 2013
  • May 26, 2014
  • May 25, 2015
  • May 30, 2016
  • May 29, 2017

Different people have different ways of spending the holiday. To those who have had a relative or friend die in service, the day is somber and one of reflection.

  • At 3pm local time, observe the National Moment of Remembrance. Spend just one minute reflecting on what these heroes have done to give us our freedom.
  • If you fly a US flag, be sure to fly it at half mast until noon.
  • Find a good charity and donate to the families of those who have lost their lives.
  • Volunteer to place flags at cemeteries.
  • Attend or participate in a parade.
  • Visit a war memorial and learn about the history of the battles, the war, and the soldiers who fought.
  • Wear red, white, and blue to show your support.

History of Memorial Day

Having a special day to honor fallen soldiers started during the Civil War. It didn't necessarily start in one place as many different communities had different days and ways that they observed the day.

The first time the day was given an official name was in 1868 when Decoration Day was observed on May 30th. Michigan was the first state to make Decoration Day an official holiday in 1871.

Over time the day became known as Memorial Day. After World War II the day was used to honor soldiers who died in all wars, rather than just the Civil War. In 1967 the name of the holiday was officially changed to Memorial Day.

In 1968 a law was passed to change the date of the holiday to the last Monday in May. This was to help create a three day weekend. Today this marks the start of summer for many businesses and many people go to the beach or take other vacations over this weekend.


Vector Ecology

The Aedes aegypti mosquito is considered the primary vector of DENV. It lives in urban habitats and breeds mostly in man-made containers. Ae. aegypti is a day-time feeder its peak biting periods are early in the morning and in the evening before sunset [19] Female Ae. aegypti frequently feed multiple times between each egg-laying period [20] . Once a female has laid her eggs, these eggs can remain viable for several months, and will hatch when they in contact with water.

Aedes albopictus, a secondary dengue vector in Asia, has spread to more than 32 states in the USA, and more than 25 countries in the European Region, largely due to the international trade in used tyres (a breeding habitat) and other goods (e.g. lucky bamboo). Ae. albopictus is highly adaptive. Its geographical spread is largely due to its tolerance of colder conditions, as an egg and adult [21, 22] . Aedes albopictus has been implicated as the primary vector of DENV in a limited number of outbreak, where Aedes aegypti is either not present, or present in low numbers [23, 24]


Fashion

If you are planning to attend the Kentucky Oaks, we encourage you to wear any color as long as it is PINK — from hats to handkerchiefs, suits to sundresses, sunglasses to stilettos! Churchill Downs invites you to THINK PINK when planning your attire for Kentucky Oaks day, in honor of the Oaks official flower — the stargazer lily.

You can show off your pink duds in the Longines Kentucky Oaks Fashion Contest, for an opportunity to win a Longines time piece. In 2021, Longines will host a virtual fashion contest on Twitter and Instagram. Post your best fashion picture using #myderbyfashion on Oaks or Derby day for a chance to win.


Substance Abuse and Mental Health Data Archive

Research shows that substance use and mental illnesses are common in the United States, affecting millions of people each year. SAMHSA collects data through multiple sources and surveys and provides access to public-use data files and documentation to support a better understanding of mental illness and substance use disorders in America.

If you would like to read descriptions of the different surveys, please check out the Data Sources page.

Publications With SAMHSA Data

The SAMHDA list of publications provides quick access to a bibliography of the peer-reviewed studies that have used SAMHSA data to advance the field of research related to mental health and substance use.

Data Source Finder

Not sure where to start? Use the Data Source Finder to learn about SAMHSA data sources and to find relevant public-use files.


Videos of vehicle rammings have become 'a meme in white supremacy circles'

Video of many of the vehicle rammings has circulated on social media, including white supremacist websites, according to MacNab, who said she has seen "revolting" commentary on videos shared to white supremacist accounts on YouTube, Facebook and Twitter.

"This has become something of a meme in white supremacy circles. There’ll be a picture of a car driving into a crowd, and then there will be a humorous remark about it. It’s definitely part of the discourse," said Daniel Byman, a senior fellow at Brookings who researches counterterrorism and Middle East security. "They’re doing a lot of kidding-not-kidding sort of humor . which is the modern white supremacist world."

Drivers striking protesters with cars: Indiana has seen at least 3 cases

Byman said earlier this summer that he's seen a meme shared by the Charlottesville killer circulating in white supremacist circles. Right-wing extremists turned the man into "a bit of a saint" after the killing, MacNab said.

Since the grand jury indictment in the Breonna Taylor case Wednesday, and the protests that have erupted in the ensuing days, the use of particular Twitter hashtags referencing such memes has more than doubled, according to Weil.

"These 'Run Them Over' memes continue to circulate. Twitter said they were going to block the hashtag All Lives Splatter, but it still remains in use," he said.


Human coronavirus circulation in the United States 2014-2017

Background: Human coronaviruses (HCoVs) -OC43, -229E, -NL63 and -HKU1 cause upper and lower respiratory tract infections. HCoVs are globally distributed and the predominant species may vary by region or year. Prior studies have shown seasonal patterns of HCoV species and annual variation in species prevalence but national circulation patterns in the US have not yet been described.

Objectives: To describe circulation patterns of HCoVs -OC43, -229E, -NL63 and -HKU1 in the US.

Study design: We reviewed real-time reverse transcription polymerase chain reaction (rRT-PCR) test results for HCoV-OC43, -229E, -NL63 and -HKU1 reported to The National Respiratory and Enteric Virus Surveillance System (NREVSS) by U.S. laboratories from July 2014-June 2017. We calculated the total number of tests and percent positive by week. For a subset of HCoV positive submissions with age and sex of the patient available, we tested for differences in age and sex across the four HCoV species using Chi Square and Kruskal Wallace tests.

Results: 117 laboratories reported 854,575 HCoV tests 2.2% were positive for HCoV-OC43, 1.0% for HCoV-NL63, 0.8% for HCoV-229E, and 0.6% for HCoV-HKU1. The percentage of positive tests peaked during December - March each year. No significant differences in sex were seen across species, although a significant difference in age distribution was noted.

Conclusions: Common HCoVs may have annual peaks of circulation in winter months in the US, and individual HCoVs may show variable circulation from year to year. Different HCoV species may be detected more frequently in different age groups. Further years of data are needed to better understand patterns of activity for HCoVs.

Keywords: Coronavirus Epidemiology Respiratory tract infection Respiratory virus.


Contents

The major components of Flutter include:

    platform
  • Flutter engine
  • Foundation library
  • Design-specific widgets
  • Flutter Development Tools (DevTools)

Dart platform Edit

Flutter apps are written in the Dart language and make use of many of the language's more advanced features. [10]

On Windows, macOS, and Linux [11] Flutter runs in the Dart virtual machine, which features a just-in-time execution engine. While writing and debugging an app, Flutter uses Just In Time compilation, allowing for "hot reload", with which modifications to source files can be injected into a running application. Flutter extends this with support for stateful hot reload, where in most cases changes to source code are reflected immediately in the running app without requiring a restart or any loss of state. [12]

For better performance, release versions of Flutter apps targeting Android and iOS are compiled with ahead-of-time (AOT) compilation. [13]

Flutter engine Edit

Flutter's engine, written primarily in C++, provides low-level rendering support using Google's Skia graphics library. Additionally, it interfaces with platform-specific SDKs such as those provided by Android and iOS. [10] The Flutter Engine is a portable runtime for hosting Flutter applications. It implements Flutter's core libraries, including animation and graphics, file and network I/O, accessibility support, plugin architecture, and a Dart runtime and compile toolchain. Most developers interact with Flutter via the Flutter Framework, which provides a reactive framework and a set of platform, layout, and foundation widgets.

Foundation library Edit

The Foundation library, written in Dart, provides basic classes and functions that are used to construct applications using Flutter, such as APIs to communicate with the engine. [10] [14]

Design-specific widgets Edit

The Flutter framework contains two sets of widgets that conform to specific design languages: Material Design widgets implement Google's design language of the same name, and Cupertino widgets implement Apple's iOS Human interface guidelines. [10] [15] [16] [17]

Flutter uses a variety of widgets to deliver a fully functioning application. These widgets are Flutter's framework architecture. [18] Flutter's Widget Catalog provides a full explanation and API on the framework.


Watch the video: April 30 - This Day in History (June 2022).


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